Prime Minister Andy Burnham will take Brexit back to the centre of the Commons agenda when MPs return from the party conference recess, delivering a statement on the first sitting day after the break.
In prepared remarks, Mr Burnham is expected to warn that failing to seek a better arrangement with the European Union would amount to a "major dereliction of duty". He will urge parliamentarians to acknowledge the economic and administrative damage he says has followed the UK's departure from the bloc.
The statement will emphasise the need for closer ties with the EU as a means to boost economic growth and to strengthen cooperation on migration control. Mr Burnham plans to highlight trade and illegal immigration as areas where renewed partnership with Brussels could deliver practical benefits for the UK.
Coming immediately after the conference recess, the intervention signals a deliberate effort by the prime minister to put Brexit back on the parliamentary agenda and to call on MPs across the House to confront its consequences. The focus, according to Downing Street, will be on pragmatic collaboration with EU partners rather than a re-run of referendum-era arguments.
Broader political reactions to the speech are likely to shape the debate in the House in the weeks ahead, as lawmakers consider how to respond to the prime minister's appeal for a change in approach to EU relations and to the challenges he identifies.